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Hace 11 horas · Vulvovaginal candidiasis (VVC) is a prevalent condition affecting a significant portion of women worldwide. Licochalcone A (LA), a natural compound with diverse biological activities, holds promise as a protective agent against Candida albicans (C. albicans) infection. This study aims to investigate the potential of LA to safeguard vaginal epithelial cells (VECs) from C. albicans infection and ...
Hace 11 horas · Digital pathology and AI firm Paige has announced the launch of a new service line based on its Foundation Models, including the world's largest multi-modal AI model in pathology and oncology. AI developers, organisations building computational pathology products, and life sciences companies will be able to license and use these Foundation ...
Hace 11 horas · Dying cells generally have two options: go quietly, or go out with a bang. The latter, while more conspicuous, is also mechanistically more mysterious.
Hace 11 horas · Transmitochondrial cybrid (cybrid) models (cybrid) system is an excellent tool to compare different mitochondria on a common defined nuclear background to understand mitochondria-specific effects on cellular properties.
Hace 11 horas · Accordingly, we proposed a diagnosis of ZAP70 deficiency based on compound biallelic variants affecting the ZAP70 gene, which was confirmed by platform-targeted exome sequencing and computational analysis of the gene. Figure 2 This is a schematic structure of the affected sites of ZAP70 protein. ZAP70 protein domains are the amino-terminal SH2 ...
Hace 11 horas · Clear-cell Renal-Cell Carcinoma (ccRCC) is the most common type of renal-cell carcinoma (RCC). In many cases, RCC patients manifest the first symptoms during the advanced stage of the disease. For this reason, immunotherapy appears to be one of the dominant treatments to achieve a resolution. In this review, we focus on the presentation of the main immune checkpoint proteins that act as ...
Hace 11 horas · In vitro angiogenesis models enable the investigation of key cellular players, signaling pathways, and environmental factors that influence blood vessel formation. Researchers can leverage various in vitro angiogenesis assays to study the effects of pro-angiogenic or anti-angiogenic agents on the different stages of blood vessel formation.
