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Hace 12 horas · AbbVie has announced that its RINVOQ (upadacitinib) is now indicated for treating polyarticular juvenile idiopathic arthritis (pJIA) and psoriatic arthritis (PsA) in paediatric patients aged two ...
Hace 12 horas · Tillæg af isatuximab (Sarclisa) til standardbehandlingen af patienter med nydiagnosticeret myelomatose, når patienterne ikke kan modtage transplantation, kan være en særdeles god idé. Det viser i hvert fald data fra IMROZ-studiet, som netop er blevet præsenteret på den årlige kongres for American Society of Clinical Oncology (ASCO). Studiet viser, at tillæg af isatuximab til ...
Hace 7 horas · The Plasma Thawer Systems Market is expected to experience steady growth in the coming years, with a projected CAGR of 6.60% during the forecasted period. This growth can be attributed to the ...
Hace 12 horas · 生物活性： 5-Aminolevulinic acid hydrochloride (5-ALA hydrochloride) 是体内血红素生物合成的中间体，是四吡咯的通用前体。. 体外： 5-氨基乙酰丙酸盐酸盐 (ALA) 是一种非荧光前体药物，可导致恶性神经胶质瘤中荧光卟啉在细胞内积聚 - 这一发现正在调查这些肿瘤的术中 ...
Hace 12 horas · 生物活性： Hyocholic Acid 是一种最早在猪体内发现的胆汁酸。. Hyocholic Acid 也可以在胆汁淤积患者的尿液样本中发现。. Hyocholic Acid 通过激活 TGR5 和抑制 FXR 促进肠内分泌细胞 GLP-1 分泌。. Hyocholic Acid 可抵抗 2 型糖尿病。. 体外： HCA (25 and 50 μM, 24 h) upregulates GLP-1 ...
Hace 12 horas · I-BET151 在大鼠中表现出低血液清除率（约 20% 肝血流量）和良好的口服全身暴露，从而导致良好的口服生物利用度。狗的高血液清除率与在狗微粒体和肝细胞中观察到的高内在清除率密切相关，而在大鼠和小鼠中观察到的低内在清除率（小鼠 IVC 1.6 mL/min/g；由于在狗身上观察到的全身暴露量较低，I ...
