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  1. www.ncbi.nlm.nih.gov › pmc › articlesCellular Senescence: Mechanisms and Therapeutic Potential

    25 de nov. de 2021 · In simple terms, cellular senescence refers to a highly stable cell cycle arrest that acts as a defence mechanism in response to different stresses—these include oncogenic activation, tumour suppressor gene inactivation, oxidative stress, telomere attrition, mitochondrial dysfunction, as well as DNA-damage causing agents, such as ...

  2. www.nature.com › articles › s41581/022/00601-zCellular senescence: the good, the bad and the unknown - Nature

    3 de ago. de 2022 · Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to cancer...

  3. www.cell.com › cell › fulltextCellular Senescence: Defining a Path Forward - Cell Press

    Cellular senescence is a cell state triggered by stressful insults and certain physiological processes, characterized by a prolonged and generally irreversible cell-cycle arrest with secretory features, macromolecular damage, and altered metabolism ( Figure 1 ).

    • Vassilis Gorgoulis, Peter D. Adams, Andrea Alimonti, Dorothy C. Bennett, Oliver Bischof, Cleo Bishop...
    • 2019

  4. en.wikipedia.org › wiki › Cellular_senescenceCellular senescence - Wikipedia

    Cellular senescence is a phenomenon characterized by the cessation of cell division. [1] [2] [3] In their experiments during the early 1960s, Leonard Hayflick and Paul Moorhead found that normal human fetal fibroblasts in culture reach a maximum of approximately 50 cell population doublings before becoming senescent.

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  6. www.nature.com › articles › s41580/020/00314-wCellular senescence in ageing: from mechanisms to ... - Nature

    16 de dic. de 2020 · Introduction. Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to...

  7. www.sciencedirect.com › science › articleCellular Senescence: Defining a Path Forward - ScienceDirect

    31 de oct. de 2019 · Cellular Senescence: Defining a Path Forward. Author links open overlay panel. Vassilis Gorgoulis 1 20 25 26. , Peter D. Adams 2 27 28. , Andrea Alimonti 3 29 30 31. , Dorothy C. Bennett 4. , Oliver Bischof 5. , Cleo Bishop 6. , Judith Campisi 7. , Manuel Collado 8. , Konstantinos Evangelou 1. , Gerardo Ferbeyre 10. , Jesús Gil 11 32. ,