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16 de dic. de 2020 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...
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3 de ago. de 2022 · 224 Citations. 177 Altmetric. Metrics. Abstract. Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged...
25 de nov. de 2021 · In simple terms, cellular senescence refers to a highly stable cell cycle arrest that acts as a defence mechanism in response to different stresses—these include oncogenic activation, tumour suppressor gene inactivation, oxidative stress, telomere attrition, mitochondrial dysfunction, as well as DNA-damage causing agents, such as ...
- 10.3390/biomedicines9121769
- 2021/12
- Biomedicines. 2021 Dec; 9(12): 1769.
11 de ago. de 2022 · Nature Medicine - Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; this Review highlights the most promising strategies for translating...
23 de may. de 2022 · Here, we describe the mechanisms, markers and biological functions of cellular senescence. We primarily focus on the concept of heterogeneity and its consequences for the identification and therapeutic targeting of senescent cells.
29 de mar. de 2022 · Senescence is a cellular state that can be induced by different stimuli and it is characterised by a stable cell cycle arrest, a secretory-associated phenotype (SASP), macromolecular damage, deregulated metabolism and characteristically-altered cellular morphology.
Cellular senescence is a stable cell cycle arrest that occurs in diploid cells and limits their proliferative life span. The first description of this phenomenon dates back to 1960s, when Hayflick and Moorhead observed that human diploid fibro-blasts in culture could reach a maximum number of cell divisions before arresting their growth (150).
