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  1. www.ncbi.nlm.nih.gov › pmc › articlesSenescence and aging: Causes, consequences, and therapeutic...

    2 de ene. de 2018 · Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related ...

    • Domhnall McHugh, Domhnall McHugh, Jesús Gil, Jesús Gil
    • 10.1083/jcb.201708092
    • 2018
    • J Cell Biol. 2018 Jan 2; 217(1): 65-77.

  2. www.ncbi.nlm.nih.gov › pmc › articlesCellular senescence in aging and age-related diseases ...

    Cellular senescence plays a direct role in chronic and age-related diseases and conditions, such as diabetes, atherosclerosis, neurovascular dysfunction, frailty, and dementias. Accumulation of senescent cells with aging contributes to multiple, age-related comorbidities that are frequently accompanied by neurodegenerative diseases, especially AD.

    • Erin O. Wissler Gerdes, Yi Zhu, B. Melanie Weigand, Utkarsh Tripathi, Terence C. Burns, Tamar Tchkon...
    • 10.1016/bs.irn.2020.03.019
    • 2020
    • 2020

  3. www.nature.com › articles › s41591/022/01923-yCellular senescence and senolytics: the path to the clinic ...

    11 de ago. de 2022 · Nature Medicine - Cellular senescence has emerged as a promising therapeutic target for disorders across the lifespan; this Review highlights the most promising strategies for translating...

  4. www.nature.com › articles › s41581/022/00601-zCellular senescence: the good, the bad and the unknown - Nature

    3 de ago. de 2022 · 224 Citations. 177 Altmetric. Metrics. Abstract. Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged...

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  6. www.nature.com › articles › s41580/020/00314-wCellular senescence in ageing: from mechanisms to ... - Nature

    16 de dic. de 2020 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...

    • Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d’Adda di Fagagna
    • 2021

  7. www.ncbi.nlm.nih.gov › pmc › articlesCellular Senescence in Brain Aging - PMC

    25 de feb. de 2021 · As we age, cognitive performance generally declines which manifests as decrements in learning and memory, attention, decision-making speed, sensory perception (vision, hearing, touch, smell, and taste), and motor coordination (reviewed in Mattson and Arumugam, 2018 ).

  8. pubmed.ncbi.nlm.nih.gov › 35953721Cellular senescence and senolytics: the path to the clinic

    One such process is cellular senescence, which entails a state of cell cycle arrest in response to damaging stimuli. Senescent cells can arise throughout the lifespan and, if persistent, can have deleterious effects on tissue function due to the many proteins they secrete.