Resultado de búsqueda
Cellular senescence plays a direct role in chronic and age-related diseases and conditions, such as diabetes, atherosclerosis, neurovascular dysfunction, frailty, and dementias. Accumulation of senescent cells with aging contributes to multiple, age-related comorbidities that are frequently accompanied by neurodegenerative diseases, especially AD.
- Senescence and aging: Causes, consequences, and therapeutic ...
Senescence is a cellular response characterized by a stable...
- Cellular senescence and senolytics: the path to the clinic
One such process is cellular senescence, which entails a...
- Senescence and aging: Causes, consequences, and therapeutic ...
11 de ago. de 2022 · A fundamental aging mechanism that has gained increasing attention is cellular senescence. Senescent cells accumulate during aging and at pathogenic sites of multiple disorders and diseases.
3 de ago. de 2022 · Cellular senescence occurs during embryonic development and can be induced by cellular impairment, including DNA damage, telomere shortening or dysfunction, oncogene activation or loss of...
8 de ago. de 2022 · Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives secondary senescence and disrupts tissue homeostasis, resulting in loss of tissue ...
- 10.1172/JCI158450
- 2022/08/08
- J Clin Invest. 2022 Aug 1; 132(15): e158450.
16 de dic. de 2020 · This Review discusses the mechanisms of cellular senescence and induction of a senescence-associated secretory phenotype, recent insights into how senescence contributes to ageing, and the ...
