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Currently, the largest genetic study in MS has analyzed 47,351 cases and 68,284 healthy controls, and has identified 233 genome-wide loci associated with MS susceptibility ( Patsopoulos and International Multiple Sclerosis Genetics Consortium 2016 ).
- Nikolaos A. Patsopoulos
- 2018
The recent use of genome wide association studies provide new tools for a better understanding of Multiple Sclerosis etiology. GWASs have identified many genes implicated in immune regulation and the next step will be to elucidate how those genetic variations influence immune cells function to drive disease development and progression.
- Pierre-Paul Axisa, David A. Hafler
- 10.1097/WCO.0000000000000319
- 2016
- 2016/06
- The Problem with MS Genetic Testing
- Is MS Hereditary?
- MS Causes
- What You Can Do
- Summary
- A Word from Verywell
Researchers have found that more than 200 genes appear to contribute to your risk of MS. It may seem like scientists should be able to devise a test based on that, however it’s not that simple. There’s still much about MS that isn’t understood.
Multiple sclerosis is not a hereditary disease. Hereditary diseases are caused purely by genetics. If you have the gene, you either have the disease or will develop it eventually. Because genetics make up part of your MS risk, it is considered a disease with a genetic component. Since people can carry the polymorphisms without ever developing MS, t...
MS doesn’t have one cause—it’s believed to be caused by a combination of genetics and epigenetic changes due to environmental factors.
While there’s no known way to prevent or delay MS, you may be able to lower your risk by modifying certain environmental factors.
No genetic tests are available for MS. Changes in 200 genes are linked to the disease, but not everyone with MS has them, and most people with these changes don’t have MS. The changes are polymorphisms, not faulty genes. MS has a genetic component but isn’t hereditary. You’re at higher risk if you have a close relative with it. Genetics and environ...
While genetic testing can’t currently predict whether you or your child will develop multiple sclerosis, it may someday be able to. Genetic research may lead to better diagnostic tests and treatments, as well. Until then, talk to your doctor about your risk factors and watch for early symptoms. Above all, focus on living a healthy lifestyle. That’s...
- Adrienne Dellwo
27 de nov. de 2017 · Genetic atlas of multiple sclerosis. The circus plot summarizes all the known MS-associated risk loci. The outer most track indicates the numbered autosomal chromosomes, while the second track shows the closest gene to the top hit within each locus (previously (more...)
- Alessandro Didonna, Jorge R. Oksenberg
- 10.15586/codon.multiplesclerosis.2017.ch1
- 2017
- 2017/11/27
7 de nov. de 2019 · A large-scale meta-analysis of multiple sclerosis (MS) genetic data identifies over 200 variants that are significantly associated with MS susceptibility. MS is a debilitating autoimmune...
- Kate Gao
- kate.gao@us.nature.com
- 2019
28 de jun. de 2023 · This study identifies the first genetic locus for multiple sclerosis severity, and highlights processes in the central nervous system (rather than autoimmunity) that play an important part in...
We summarise how recent, large GWAS have led to our current understanding of the genetic architecture of multiple sclerosis and discuss how these results inform disease biology. We also assess the role of environmental risk factors, and the implications for treatment and future potential for personalised medicine.
