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What about if you’re still coughing off after prednisone, what should you do? It’s probably not going to help you. If you have prednisone for cough being prescribed and you’re like, is this worth it? It’s generally not worth it unless you have one of those five reasons. What else could they possibly give you for cough instead of prednisone?
16 de abr. de 2020 · New evidence suggests that postnasal drip, acid reflux, or even forceful coughing in and of itself can aggravate nerve endings in the "cough centers" of the airways. These aggravated nerve endings then overreact to many other triggers, such as smoke, perfume, or temperature changes, causing an overwhelming urge to cough.
- Monique Tello, MD, MPH
- (877) 649-9457
- 4 Blackfan Circle, 4th Floor, Boston, 02115, MA
- hhp_info@health.harvard.edu
1 de dic. de 2023 · Steroid medications like dexamethasone and prednisone can help some kinds of coughs. Learn when your cough may require steroids.
- Explanation For The Choice of Comparators
- Intervention Description
- Criteria For Discontinuing Or Modifying Allocated Interventions
- Strategies to Improve Adherence to Interventions
- Relevant Concomitant Care Permitted Or Prohibited During The Trial
- Provisions For Post-Trial Care
- Outcomes
- Participant Timeline
- Sample Size
- Recruitment
Patients in the control group will receive 10 placebo pills of 20 mg (40 mg of placebo). Placebo pills are described in detail in the next section. Placebo will be used as a comparator in this study to prevent various biases (in particular as the primary endpoint is patient-reported). Potential implications on a limited applicability of the results...
The expected duration of participation in the study is around 3 months. This includes the day 0 (randomization) study activities, the treatment period of 5 days and four follow-up phone calls. At the baseline visit (day 0), patients will receive pre-randomized identically looking, individually labelled medication glass jars with daily doses of 40 m...
Due to the short intervention of 5 days, no treatment modifications are planned unless in the (unlikely) occasion of any side effects. Even though the likelihood is very low, adverse events (AE), such as allergic reactions to the study drug, psychotic or pre-psychotic episode, or serious adverse events (SAE), sepsis, venous thromboembolism, fractur...
In order to facilitate adherence to the study intake schedule, participants are given a written medication guide. GPs will inform patients in depth on the importance to adhere to the 5-day medication for ensuring the effectiveness of treatment. They will emphasize the value to the trial conduct of participants’ availability for the follow-up phone ...
Apart from the use of corticosteroids, any co-treatment or co-medication (i.e. antitussives, inhalation, herbal teas, and homoeopathic pharmaceuticals) is permitted. Any other medical intervention used by study participants will be recorded in the electronic Case Report Forms (eCRF) to analyse the potential influence on outcomes. Throughout the tri...
Corticosteroid potential side effects and complications will be systematically recorded from the time of randomization until the last follow-up call at 3 months. In case of persistent coughing at 3 months from randomization, the patient will be advised to visit the GP again for a new assessment and necessary further investigations. GPs and research...
The primary outcome is the cough-related QoL at 14 days after randomization. We will use the validated Leicester Cough Questionnaire (LCQ) score [18,19,20,21] to assess the impact of the study medication on patients’ QoL (mean difference between arms measured 14 days after randomization). Total and individual LCQ domain scores will be calculated. T...
General practitioners will enrol approximately 5 but not more than 10 participants from patients presenting for a consultation due to post-infectious cough (baseline visit) over a period of 18 months until the sample size is reached (N= 204). Eligible patients who consent to the study will be randomly assigned (1:1) by their GP to the active treatm...
Sample size was estimated to have 80% power to detect the minimal clinically important difference (MCID) set at 1.3 points LCQ . To be able to detect an MCID of 1.3 points with a power of 80%, a total of 204 patients need to be recruited for both arms. This was calculated without considering intra-patient correlation (IPC) correlation rho (ρ) betwe...
A total of 204 eligible patients with post-infectious cough will be recruited from general practices in North-western and Central Switzerland within a period of approximately 18 months. The geographical area is large enough to recruit the required number of patients in the indicated timeframe as nearly 40% of adults can be affected by post-infectio...
- Christoph Merlo, Stefan Essig, D. Oana Brancati-Badarau, Jörg Daniel Leuppi, Benjamin Speich, Benjam...
- 2020
14 de ene. de 2024 · Acute bronchitis typically lasts between one and three weeks, while chronic bronchitis by definition lasts for three months or more per year for at least two years. In some cases, chronic bronchitis may be permanent. When it occurs with decreased airflow, it is called chronic obstructive pulmonary disease (COPD).
25 de feb. de 2019 · After multivariable analysis, a history of asthma, dysphagia, and the presence of a barking cough or wheezing were associated with prescribing oral steroids (Table 4), but there was no longer an independent relationship between oral steroids and the presence of a wet or productive cough.
