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11 de oct. de 2017 · Purpose of Review. The genetic susceptibility and dominant protection for type 1 diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with minor risk variants, have long been thought to shape the T cell receptor (TCR) repertoire and eventual phenotype of autoreactive T cells that mediate β-cell destruction.
- Laura M. Jacobsen, Amanda Posgai, Howard R. Seay, Michael J. Haller, Todd M. Brusko
- 2017
17 de nov. de 2021 · Here, we will review current knowledge about TCR repertoires and clonotypes specific for T1D and address the knowledge gaps to develop TCR biomarkers that can stratify individuals throughout the stages of T1D development.
- Maki Nakayama, Aaron W. Michels
- Front Immunol. 2021; 12: 777788.
- 10.3389/fimmu.2021.777788
- 2021
2 de feb. de 2024 · Type 1 diabetes (T1D) is an autoimmune disease that results in the killing of pancreatic islet β-cells, leading to metabolic failure requiring lifelong insulin treatment. T1D occurs in...
13 de jun. de 2019 · The role of T cells as essential cellular constituents of disease progression has motivated research consortium efforts to develop T-cell biomarkers in T1D, with attention to two broad classes of markers, namely, 1) antigen specific (i.e., captured by assays that measure the number and/or function of T cells specific for β-cell autoantigens) and...
2 de feb. de 2021 · Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing β cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms.
- Matthew Clark, Charles J Kroger, Qi Ke, Roland M Tisch
- 10.3389/fimmu.2020.615371
- 2021
- Front Immunol. 2020; 11: 615371.
We analyzed islet samples obtained from seven T1D and seven nondiabetic organ donors for T cell infiltration and T cell receptor (TCR) sequence repertoires . The T1D donors were children, adolescents, or young adults and had T1D for relatively short periods of time, months to a few years, except one donor who had had diabetes for 15 y.
Abstract. Critical insights into the etiology of type 1 diabetes (T1D) came from genome-wide association studies that unequivocally connected genetic susceptibility to immune cell function. At the top of the susceptibility are genes involved in regulatory T-cell (Treg) function and development.
