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  1. Sir Augustus Frederick d'Este, KCH (13 January 1794 – 28 December 1848) was a relative of the British royal family and the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made. He was the only son of Prince Augustus Frederick, Duke of Sussex and his wife Lady Augusta Murray.

  2. Prince Augustus, Duke of Sussex, by Henri-Pierre Danloux, c. 1794. While travelling in Italy, the prince met Lady Augusta Murray (1768–1830), the second daughter of the 4th Earl of Dunmore. The couple secretly married in Rome on 4 April 1793. The King's minister of Hanover affairs Ernst zu Münster was sent to Italy to escort him back to London.

  3. The House of Este ( UK: / ˈɛsti / EST-ee, [7] US: / ˈɛsteɪ / EST-ay, [8] [9] Italian: [ˈɛste]) is a European dynasty of North Italian origin whose members ruled parts of Italy and Germany for many centuries. The original House of Este's elder branch, which is known as the House of Welf, included dukes of Bavaria and of Brunswick.

  4. Augusto, duque de Sussex (August Federick; Londres; 27 de enero de 1773- Londres, 21 de abril de 1843), fue un príncipe del Reino Unido y miembro de la familia real británica desde su nacimiento, como el noveno de los quince hijos de los reyes Jorge III del Reino Unido y Carlota, hasta su muerte. Fue el primer duque de Sussex entre 1801 y 1843.

  5. Sir Augustus Frederick D’Esté (1794–1848) was an illegitimate royal child, a bachelor, an active member of the Aborigines Protection Society, and the earliest known person diagnosed with multiple sclerosis. For 24 years D’Esté kept a diary, currently held in the Royal College of Physicians’ archives, which documents what he called ‘my case’.

  6. 12 de ene. de 2024 · Joanne Hayle. Updated: Jan 12, 2024 12:53 AM EST. Prince Augustus Frederick, Duke of Sussex in the ceremonial robes of a knight companion of the Order of the Thistle. Wikipedia Public Domain. The Academic Prince Augustus Frederick. Prince Augustus Frederick was the 9th child and 6th son of King George III and Charlotte of Mecklenberg-Strelitz.