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Revisado/Modificado abr. 2023. El síndrome de Eisenmenger es una complicación de los cortocircuitos izquierda-derecha intracardíaca o aórtica a la arteria pulmonar no corregidos. Con el paso del tiempo, puede desarrollarse un aumento de la resistencia pulmonar, que a largo plazo ocasiona hipertensión pulmonar grave, cortocircuito ...
20 de sept. de 2018 · Compounds containing the benzothiazole N-oxide scaffold not only bind covalently to this residue, but are reversible inhibitors through the formation of Meisenheimer complexes. This mechanism of kinase inhibition results in compounds that can target PLK1 with high selectivity, while avoiding issues with irreversible covalent binding and interaction with other thiol-containing molecules in the ...
This chapter discusses Meisenheimer complexes. Spectroscopic and crystallographic methods have largely confirmed Meisenheimer's formula for the stable adducts from alkyl picrates and alkoxides. Meisenheimer associated with the para-nitro group is delocalized about the ring and in the nitro-groups. The alkoxy groups at the sp3-hybridized C1 lies ...
Un complejo de Meisenheimer o complejo de Jackson-Meisenheimer en química orgánica es un aducto de reacción 1: 1 entre un areno que lleva grupos sustractores de electrones y un nucleófilo . Estos complejos se encuentran como intermedios reactivos en la sustitución aromática nucleófila, pero también se conocen sales de Meisenheimer estables y aisladas. [1] [2] [3]
18 de may. de 2020 · In this work we report a computational study about the aza-SNAr mechanism in fluorine- and chlorine-containing azines with the aim to unravel the physical factors that determine the reactivity patterns in these heterocycles towards propylamine. The nature of the reaction intermediate was analyzed in terms of
Also known as the Meisenheimer Jackson salt, the stable intermediate for cer-tain S N Ar reactions. Sanger s reagent , ipso attack ipso substitution Example 1 7 Example 2 9 The reaction using Sanger s reagent is faster than usin g the corresponding chloro-, bromo-, and iododinitrobenzene the fluoro-Meisenheimer complex is the most
20 de sept. de 2018 · Due to recent renewed interest in covalently binding inhibitors as a class of drugs, and the plethora of targets that can be inhibited using this approach, these compounds represent prototypes for the design of kinase inhibitors and, in fact, inhibitors in general that exploit the Meisenheimer complex to generate potent and selective compounds that potentially also avoid toxicity issues ...
