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George Emil Palade, o autobiografie. George Emil Palade este singurul om de ştiinţă de origine română care a luat premiul Nobel. Iată autobiografia pe care acesta a scris-o în 1974, cu ocazia decernării premiului Nobel pentru Medicină, pentru contribuţiile la înţelegerea structurii şi organizării funcţionale a celulei.
George Palade1 was born in Jassy, Romania, in 1912 to a family that greatly valued education. His mother was a teacher and his father, a professor of philosophy, which explains why he acquired “a great respect for books, scholars, and education early in life” (Palade, 1975b). He was drawn to science and medicine and entered medical school ...
Pancreatic tissue, (guinea pig) homogenized in 0.88 M sucrose, was fractionated by differential centrifugation into a nuclear, zymogen, mitochondrial, microsomal, and final supernatant fraction. The components of the particulate fractions were identified with well known intracellular structures by e …
Description. George Palade and Philip Siekevitz at the electron microscope, 1964. Courtesy of The Rockefeller Archive Center. Download Medium Thumbnail.
George Emil Palade died on 7 October at the age of 95. He was among the greatest scientists of the twentieth century, whose ... studies with Philip Siekevitz in his lab on the
what is now Rockefeller University, Palade focused on membranes of the endoplasmic reticulum (ER) and elucidated the basis of protein synthesis and secretion. Palade’s work in the 1950s established the ribosome as the seat of protein synthesis in the cytoplasm. In the 1950s and 1960s, he teamed with Philip Siekevitz and then with Lewis
In the following years, Palade and Siekevitz went on to show that the attached RNPs were the exclusive source of newly synthesized secretory proteins. Although the initial studies on microsomes were carried out with liver, Palade and Siekevitz chose the guinea pig pancreas for their classical work on the se-cretory pathway.
