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Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene. [5] [6] [7] It is a member of the alpha/beta fold hydrolase family. [8] Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester - and amide -bond-containing drugs such as cocaine and heroin.
Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene. We have determined the crystal structures of ...
14 de abr. de 2016 · Xu, J. et al. Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis. Hepatology 59, 1761–1771, 10.1002/hep.26714 (2014).
Introduction. Mammalian carboxylesterases (CES, EC 3.1.1.1) are a well conserved multi-gene family of α,β-hydrolase-fold proteins that catalyze the hydrolysis of a vast array of endogenous and exogenous substrates including environmental toxins and drugs. 1-3 Though generally ignored at the clinical level, carboxylesterase-mediated hydrolysis plays an important role in the disposition of a ...
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%-95% of total hydrolytic activity in the liver and plays a crucial role in the metabolism of a wide range of drugs (especially ester-prodrugs), pesticides, environmental ...
1 de mar. de 2020 · Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%–95% of total hydrolytic activity in the liver and plays a crucial role in the metabolism of a wide range of drugs (especially ester-prodrugs), pesticides, environmental pollutants, and endogenous compounds.
5 de feb. de 2013 · Mammalian carboxylesterases (EC 3.1.1.1) are a well conserved multigene family of α,β-hydrolase fold proteins that catalyze the hydrolysis of a vast array of endogenous and exogenous substrates including many environmental toxins and drugs. 1-3 Though generally ignored at the clinical level, carboxylesterase-mediated hydrolysis plays an important role in the disposition of a number of widely ...
