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5 de abr. de 2019 · The Nobel Prize in Physiology or Medicine 2002 was awarded jointly to Sydney Brenner, H. Robert Horvitz and John E. Sulston "for their discoveries concerning genetic regulation of organ development and programmed cell death'"
The Nobel Prize in Physiology or Medicine 2002 was awarded jointly to Sydney Brenner, H. Robert Horvitz and John E. Sulston "for their discoveries concerning genetic regulation of organ development and programmed cell death'".
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Sydney Brenner was one of the first to view James Watson and Francis Crick’s double helix model of DNA in April 1953. The 26-year-old biologist from South Africa was then a graduate student at the University of Oxford, UK. So enthralled was he by the insights from the structure that he determined on the spot to devote his life to understanding genes.
Iconoclastic and provocative, he became one of the leading biologists of the twentieth century. Brenner shared in the 2002 Nobel Prize in Physiology or Medicine for deciphering the genetics of programmed cell death and animal development, including how the nervous system forms. He was at the forefront of the 1975 Asilomar meeting to discuss the appropriate use of emerging abilities to alter DNA, was a key proponent of the Human Genome Project, and much more. He died on 5 April.
Brenner was born in 1927 in Germiston, South Africa, to poor immigrant parents. Bored by school, he preferred to read books borrowed (sometimes permanently) from the public library, or to dabble with a self-assembled chemistry set. His extraordinary intellect — he was reading newspapers by the age of four — did not go unnoticed. His teachers secured an award from the town council to send him to medical school.
Brenner entered the University of the Witwatersrand in Johannesburg at the age of 15 (alongside Aaron Klug, another science-giant-in-training). Here, certain faculty members, notably the anatomist Raymond Dart, and fellow research-oriented medical students enriched his interest in science. On finishing his six-year course, his youth legally precluded him from practising medicine, so he devoted two years to learning cell biology at the bench. His passion for research was such that he rarely set foot on the wards — and he initially failed his final examination in internal medicine.
In 1952 Brenner won a scholarship to the Department of Physical Chemistry at Oxford. His adviser, Cyril Hinshelwood, wanted to pursue the idea that the environment altered observable characteristics of bacteria. Brenner tried to convince him of the role of genetic mutation. Two years later, with doctorate in hand, Brenner spent the summer of 1954 in the United States visiting labs, including Cold Spring Harbor in New York state. Here he caught up with Watson and Crick again.
•Nature Medicine: My Life in Science by Sydney Brenner
•Life's code script
- Errol Friedberg
- 2019
5 de abr. de 2019 · Pioneering molecular biologist Sydney Brenner has died, aged 92. Among Brenner’s most notable achievements was turning the Caenorhabditis elegans nematode worm into a model system for...
- Holly Else
- 2019
Sydney Brenner CH FRS FMedSci MAE (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston.
Conocido por su penetrante visión científica y mordaz ingenio, Brenner, durante muchos años, fue escritor de una columna de publicación periódica en la revista Current Biology, contribuyendo de esta manera a la divulgación científica.
26 de abr. de 2024 · Sydney Brenner was a South-African born biologist who, with John E. Sulston and H. Robert Horvitz, won the Nobel Prize for Physiology or Medicine in 2002 for their discoveries about how genes regulate tissue and organ development via a key mechanism called programmed cell death, or apoptosis.
