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George Emil Palade, o autobiografie. George Emil Palade este singurul om de ştiinţă de origine română care a luat premiul Nobel. Iată autobiografia pe care acesta a scris-o în 1974, cu ocazia decernării premiului Nobel pentru Medicină, pentru contribuţiile la înţelegerea structurii şi organizării funcţionale a celulei.
George Emil Palade (November 19, 1912 --- October 7, 2008) was a Romanian--American cell biologist and biophysicist. In 1974, he shared the Nobel Prize in Physiology or Medicine with Albert Claude and Christian de Duve, for discovering the cellular vacuole. Palade also received the U.S. National Medal of Science in Biological Sciences for ...
George Palade1 was born in Jassy, Romania, in 1912 to a family that greatly valued education. His mother was a teacher and his father, a professor of philosophy, which explains why he acquired “a great respect for books, scholars, and education early in life” (Palade, 1975b). He was drawn to science and medicine and entered medical school ...
Philip Siekevitz’s career proceeded along three phases marked by seminal contribu - tions that opened up new avenues of re-search. The first phase was in the field of protein synthesis, in which he developed the first in vitro system using defined cell fractions. Then, in collaboration with George Palade, he demonstrated the cen-
In the following years, Palade and Siekevitz went on to show that the attached RNPs were the exclusive source of newly synthesized secretory proteins. Although the initial studies on microsomes were carried out with liver, Palade and Siekevitz chose the guinea pig pancreas for their classical work on the se-cretory pathway.
Pancreatic tissue, (guinea pig) homogenized in 0.88 M sucrose, was fractionated by differential centrifugation into a nuclear, zymogen, mitochondrial, microsomal, and final supernatant fraction. The components of the particulate fractions were identified with well known intracellular structures by e …
Description. George Palade and Philip Siekevitz at the electron microscope, 1964. Courtesy of The Rockefeller Archive Center. Download Medium Thumbnail.
