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  1. 22 de jun. de 2023 · Here, we demonstrate that malignant plasma cells release mtDNA, a form of mtDAMPs, into the myeloma BM microenvironment, which in turn activates macrophages via STING signaling. We establish the functional role of these mtDAMP-activated macrophages in promoting disease progression and retaining MM cells in the protumoral BM microenvironment.

  2. In April 1904, he married Charlotte Hellmich. The couple had five children. In January 1938, his daughter Dorothea “Dorie” became engaged to Sturmbannführer in the Waffen SS, Karl-Heinz Keitel, General Wilhelm Keitel’s eldest son, born on the 02-02-1914, in Wolfenbüttel. They were married in May the same year.

  3. 1 de dic. de 2021 · @article{Mistry2021FreeFT, title={Free fatty-acid transport via CD36 drives $\beta$-oxidation-mediated hematopoietic stem cell response to infection}, author={Jayna J. Mistry and Charlotte Hellmich and Jamie A. Moore and Aisha Jibril and Iain C. Macaulay and Mar Moreno-Gonzalez and Federica Di Palma and Naiara Beraza and Kristian M. Bowles and Stuart A. Rushworth}, journal={Nature ...

  4. 15 de nov. de 2022 · Charlotte Hellmich, Edyta Wojtowicz, Rebecca S Maynard, Katherine Hampton, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Charlotte L Utting, Iain Macauley, Kristian M Bowles, Stuart A Rushworth; Mitochondrial Membrane Potential Defines the HSC Population with Serial Repopulating Potential in Young but Not Aged Animals.

  5. 5 de nov. de 2020 · Charlotte Hellmich, Jayna J Mistry, Jamie A Moore, Aisha Jibril, Kristian M Bowles, Stuart A Rushworth; Mitochondrial Function Is Impaired in a Subset of Aged Haematopoietic Stem Cells in Response to Infection.

  6. 1 de jul. de 2021 · Charlotte Hellmich, Jayna J. Mistry, Amelia Lambert, Jamie A. Moore, Aisha Jibril, Angela Collins, Kristian M. Bowles, Stuart A. Rushworth; Abstract 1048: Targeting BCL-2 and CD38 in models of acute myeloid leukemia reduces tumour burden.

  7. Charlotte Hellmich, Rebecca H. Horton, Edyta E. Wojtowicz, Aisha Jibril, Matthew Jefferson, Thomas Wileman, Naiara Beraza, Kristian M. Bowles, Stuart A. Rushworth; Affiliations Jamie A. Moore Jayna J. Mistry Charlotte Hellmich Rebecca H. Horton Edyta E. Wojtowicz Aisha Jibril Matthew Jefferson Thomas Wileman Naiara Beraza