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Hace 1 día · Survodutide is a glucagon/GLP-1 receptor dual agonist with a novel mechanism of action, and the first to show this level of fibrosis benefit in a Phase II MASH trial after 48 weeks of treatment.5,6 The glucagon agonist component in survodutide has the potential to increase energy expenditure7,8 and has a direct impact in the liver, which could ...
Hace 1 día · A total of 293 randomly assigned participants received at least one dose of survodutide or placebo. Improvement in MASH with no worsening of fibrosis occurred in 47% of the participants in the ...
Hace 5 horas · "MASH is expected to impact more than 19 million adults in the U.S. by 2039 2 and based on the study results, we believe tirzepatide may have the potential to help people living with this disease." Lilly is engaged with regulatory authorities on the next steps for tirzepatide for the treatment of MASH. About SYNERGY-NASH
Hace 1 día · Survodutide, a glucagon/GLP-1 receptor dual agonist, improved MASH with no worsening of fibrosis, reduced liver fat content, and improved fibrosis by ≥ 1 stage in a phase 2 trial. New phase 2 data for survodutide are showcasing the dual glucagon and glucagon-like peptide-1 (GLP-1) receptor agonist’s ability to improve metabolic dysfunction ...
Hace 4 días · Viking's MASH drug scored where Madrigal's didn't, but shares fall on lack of direction. Viking Therapeutics is doing some early work on co-formulating VK2735 and VK2809, which would pair an ...
Hace 3 días · Lilly had hinted at the study’s success earlier this year, but the full data will provide a more complete view of tirzepatide’s potential. The abstract’s release comes one day after Viking Therapeutics released trial data for its MASH pill VK2809 and less than two months after Madrigal Pharmaceuticals won U.S. approval of the first MASH drug.
Hace 3 días · Lilly’s fibrosis data come after the company unveiled positive midstage results in MASH in early February. At the time, Lilly said tirzepatide helped 74% of overweight or obese adults with MASH ...
