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Hace 2 días · Cellular senescence has been classically described as a stable cell cycle arrest that develops in response to stress or damage, thereby triggering multiple intracellular phenotypic changes. In ...
Hace 2 días · Cellular senescence was first described approximately 60 years ago by Hayflick and Moorhead [].They observed that normal human fibroblasts have a finite proliferative capacity in culture and termed the cell cycle arrest at the exhaustion of this capacity “replicative senescence;” the word “senescence” is derived from the Latin word senex, meaning “old.”
Hace 5 días · Cellular senescence is characterized by proliferation and migration exhaustion, senescence-associated secretory phenotype (SASP), and oxidative stress. Senescent vascular smooth muscle cells (VSMCs) contribute to cardiovascular diseases and atherosclerotic plaque instability.
Hace 4 días · Senescence is the process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing cell death. Senescence can be induced by unrepaired DNA...
Hace 1 día · The study demonstrates that a significant portion of adult human pancreatic beta cells activate a gene called p16, which indicates that they are in an aging-like state, termed cellular senescence.
Hace 2 días · To understand the mechanism of senescence in fibroblasts and relationship between minority MOMP and senescence, we examined the progression of cellular senescence occurring in the presence or absence of QVD-OPH (Figure 2a). JC1 staining showed that QVD-OPH effectively alleviated the reduction in mΔψ that was induced by IR or H 2 O 2 (Figure ...
Hace 5 días · Cellular senescence as one of the hallmarks of aging and how the manifestation of a senescence-associated secretory phenotype contributes to age-related cardiac and vascular pathologies, including systemic atherosclerosis, valvular disease, hypertension and stroke, is explored by Manish Kumar, MD, et al., in JACC: Basic to Translational Science.
