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  1. Hace 2 días · Nicholson won his next Academy Award for Best Actor in the romantic comedy As Good as It Gets (1997), his third film directed by James L. Brooks. He played Melvin Udall, a "wickedly funny", [64] mean-spirited novelist with obsessive-compulsive disorder. "I'm a studio Method actor ", he said.

  2. Hace 5 días · The legendary actor explained, “There’s a sense of hopelessness and absurdity to his life and those are philosophical kinds of issues that have always been very close to my heart.”. Nicholson stressed that he doesn’t take a “dim view of the world” but that he merely understands the “feelings and moods” of the most introspective ...

  3. Hace 4 días · Chinatown is a movie that is so good it keeps my ego in check, and so good that it also inspires me to believe in why screenwriting matters. Regarded as one of the greatest movies of all time, Chinatown is a neo-noir mystery film directed by Roman Polanski and written by Robert Towne. Set in 1937 Los Angeles, the film stars Jack Nicholson as J ...

  4. Hace 5 días · We review evidence for a novel signaling mechanism based on a little-known peptide, T14. T14 could drive neurodegeneration as an aberrantly activated process of plasticity selective to interconnecting subcortical nuclei, the isodendritic core, where cell loss starts at the pre-symptomatic stages of the disease.

  5. Hace 3 días · La enfermedad de Alzheimer es la forma más común de demencia, una afección neurodegenerativa que afecta a la memoria; actualmente todavía no existe una cura. En México se estima que para 2023 ya existían más de 350,000 personas afectadas por la enfermedad, según un informe de la Universidad Autónoma de Guadalajara.

  6. Hace 4 días · In The Notebook, a romantic drama film, an elderly man reads a love story to a woman with Alzheimer's disease in a nursing home, recounting their passionate relationship during World War II. Themes of love, loss, and enduring devotion are explored as the couple's story unfolds, with Ryan Gosling and Rachel McAdams portraying the young couple in the lead roles.

  7. Hace 2 días · Apocalypse Now. Apocalypse Now is a 1979 American epic war film produced and directed by Francis Ford Coppola. The screenplay, co-written by Coppola, John Milius, and Michael Herr, is loosely based on the 1899 novella Heart of Darkness by Joseph Conrad, with the setting changed from late 19th-century Congo to the Vietnam War.