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Hace 1 día · Department of Pulmonary and Critical Care Medicine, School of Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, P.R. China. Lu Guo. Department of Respiratory Diseases, Sir Run Run ShawHospital, Zhejiang University School of Medicine, Hangzhou, P.R. China. Guofeng Ma
Hace 1 día · Highly enantioselective [1,3] sigmatropic rearrangement represents a grand challenge in asymmetric organocatalysis. Herein, we disclose a chiral phosphoramide (R)-NPA-Cy mediated [1,3] sigmatropic rearrangement of 2-alkoxy indoles to access a diverse array of highly enantio-enriched oxindoles. The catalyst displayed good to high chiral control (89–99% ee) while maintaining a high efficiency ...
Hace 4 días · Lingnan Resource Sub-center of the National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jinan University, Guangzhou, China. Correspondence. Hui Cao, College of Pharmacy, Jinan University, Guangzhou 511400, China. Email: [email protected]
Hace 4 días · e School of Clinical Medicine, Shandong First Medical University, Jinan, China Abstract Co-loading of sonosensitizers and chemotherapeutic drugs into nanocarriers can improve the biocompatibilities, stabilities, and targeting of drugs and reduce the adverse reactions of drugs, providing a robust platform to orchestrate the synergistic interplay between chemotherapy and sonodynamic therapy (SDT ...
Hace 4 días · Crotonylation, a crotonyl-CoA-based non-enzymatic protein translational modification, affects diverse biological processes, such as spermatogenesis, tissue injury, inflammation, and neuropsychiatric diseases. Crotonylation shows decreased in hepatocellular carcinomas (HCCs), but the mechanism remains unknown. In this study, we aim to describe the role of glutaryl-CoA dehydrogenase (GCDH) in ...
Hace 3 días · Premature ovarian insufficiency (POI), which is characterized by primary or secondary amenorrhea and elevated levels of gonadotropins before 40 years old, is one of major causes of infertility in young women[1]. The phenotype of POI is heterogeneous, including isolated (nonsyndromic) and syndromic forms, such as Perrault syndrome (PS) and blepharophimosis-epicanthus syndrome type 1 (BPES1)[2 ...
Hace 4 días · Methods. Data was collected from 9 to 12 years old children (including their parents) in Shandong Province in 2018. Participants self-completed a hard-copy questionnaire including Child Health Utility 9D (CHU9D), Pediatric Quality of Life Inventory (PedsQL)™ 4.0 Short Form 15 Generic Core Scales (hereafter the PedsQL™), Student’s Life Satisfaction Scale (SLSS), as well as information on ...
