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Hace 5 días · Here, we review the roles of centrosomes in the early developing mouse and during organ formation. Mammalian cells respond to centrosome loss-of-function by activating the mitotic surveillance pathway, a timing mechanism that, when a defined mitotic duration is exceeded, leads to p53-dependent cell death in the descendants.
Hace 19 horas · Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mitochondrial matrix.
Hace 5 días · HA is a major GAG component pivotal for preserving the integrity and functionality of the mammalian ECM. To modulate HA homeostasis, we conducted both overexpression (OE) and knockout (KO) of the hyaluronidase TMEM2 in human fibroblasts, a cell type that generates and secretes a large amount of ECM components, including HA (Figures 1 A, S1 A, and S1B), and is a sentinel that controls local ...
Hace 19 horas · At the transcript level, we found no or slight changes in the abundance of mRNA levels of these genes between in vitro and in vivo MII oocytes in mice and humans, except that Cnot8 decreased ...
Hace 1 día · imageimageTransposable elements (TEs) are selfish genetic modules that have, in certain contexts, evolved into modulators of mammalian gene expression. This study provides evidence for a role of TEs in promoting an inflammatory response that is ...
Hace 1 día · Mitochondria are membrane-bound cell organelles (mitochondrion, singular) that generate most of the chemical energy needed to power the cell's biochemical reactions. Chemical energy produced by the mitochondria is stored in a small molecule called adenosine triphosphate (ATP).
Hace 4 días · The hormone prolactin (PRL) is best recognised for its indispensable role in mammalian biology, specifically the regulation of lactation.
![1: Schematic of the components of a mammalian cell [129]. | Download ...](https://mx.images.search.yahoo.com/search/images?q=mammalian+cell+in+humans&ei=UTF-8&fl=0&rd=r2&norw=1&age=1w&hsimp=yhs-elex_22find&hspart=Elex&fr=yhs-Elex-elex_22find&th=98.7&tw=124.8&imgurl=https%3A%2F%2Fwww.researchgate.net%2Fprofile%2FXiujun-Zheng%2Fpublication%2F349582074%2Ffigure%2Fdownload%2Ffig9%2FAS%3A994924270997510%401614219839560%2FSchematic-of-the-components-of-a-mammalian-cell-129.png&rurl=https%3A%2F%2Fwww.researchgate.net%2Ffigure%2FSchematic-of-the-components-of-a-mammalian-cell-129_fig9_349582074&size=150KB&name=1%3A+Schematic+of+the+components+of+a+mammalian+cell+%5B129%5D.+%7C+Download+...&oid=3&h=538&w=680&turl=https%3A%2F%2Ftse1.mm.bing.net%2Fth%3Fid%3DOIP.H3koTuwaxKgWn2i1ib3pzgHaF3%26pid%3DApi%26rs%3D1%26c%3D1%26qlt%3D95%26w%3D124%26h%3D98&tt=1%3A+Schematic+of+the+components+of+a+mammalian+cell+%5B129%5D.+%7C+Download+...&sigr=TYBvQwTezxKS&sigit=qtZSt1cPmrWB&sigi=.kZouQ56rgm7&sign=_IST1ZtGGs_8&sigt=_IST1ZtGGs_8 "1: Schematic of the components of a mammalian cell [129]. | Download ...")
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