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Shizuo Akira (審良 静男, Akira Shizuo) (born January 27, 1953, in Higashiōsaka) is a professor at the Department of Host Defense, Osaka University, Japan. He has made ground-breaking discoveries in the field of immunology, most significantly in the area of innate host defense mechanisms.
Overview. Innate immunity is a defense system triggered by pattern recognition receptors, which recognize various pathogens such as bacteria, fungi, and viruses, and induce the production of inflammatory factors to trigger immune responses.
Having concurrently served as the Director for WPI Immunology Frontier Research Center (IFReC), Osaka University from 2007 to 2019, he was appointed as SA Professor at IFReC and concurrently RIMD in 2018.
Toll-like receptors: critical proteins linking innate and acquired immunity. S Akira, K Takeda, T Kaisho. Nature immunology 2 (8), 675-680. , 2001. 6498. 2001. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. F Heil, H Hemmi, H Hochrein, F Ampenberger, C Kirschning, S Akira, ...
Shizuo Akira Osteoclasts are multinucleated cells formed by fusion of mononuclear precursors in response to receptor activator of nuclear factor κB (NF-κB) ligand (RANKL).
19 de ene. de 2006 · Shizuo Akira. Nature Immunology 7 , 131–137 ( 2006) Cite this article. 25k Accesses. 1424 Citations. 16 Altmetric. Metrics. Abstract. Induction of the antiviral innate immune response depends...
23 de may. de 2022 · Professor Akira had discovered that these Toll-like receptors played an important role in linking innate immunity and adaptive immunity, which had previously been considered two completely separate systems; this completely overturned conventional wisdom in the field of immunology.
