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Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ...
Cholinesterase inhibitors (also called acetylcholinesterase inhibitors) are a group of medicines that block the normal breakdown of acetylcholine. Acetylcholine is the main neurotransmitter found in the body and has functions in both the peripheral nervous system and the central nervous system.
Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds.
- Mirjana B Colović, Danijela Z Krstić, Tamara D Lazarević-Pašti, Aleksandra M Bondžić, Vesna M Vasić
- 10.2174/1570159X11311030006
- 2013
- 2013/05
El inhibidor de la acetilcolinesterasa, inhibidor de la colinesterasa, anticolinesterasa o anticolinesterásico es un compuesto químico farmacológico que inhibe la enzima colinesterasa impidiendo que se destruya la acetilcolina liberada, produciendo como consecuencia un aumento en la concentración y en la duración de los efectos ...
Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate ), and a terminal oxygen .
Acetylcholinesterase inhibitors (AChEIs) and the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine are widely utilized worldwide in the treatment of Alzheimer's disease and other dementias.
