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Acetylcholinesterase inhibitors (AChEIs) also often called cholinesterase inhibitors, inhibit the enzyme acetylcholinesterase from breaking down the neurotransmitter acetylcholine into choline and acetate, thereby increasing both the level and duration of action of acetylcholine in the central nervous system, autonomic ganglia and ...
- Cholinesterase inhibitor
Cholinesterase inhibitors (ChEIs), also known as anti-...
- Cholinesterase inhibitor
Cholinesterase inhibitors (ChEIs), also known as anti- cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine or butyrylcholine. This increases the amount of the acetylcholine or butyrylcholine in the synaptic cleft that can bind to muscarinic receptors, nicotinic receptors and others.
Cholinesterase inhibitors (also called acetylcholinesterase inhibitors) are a group of medicines that block the normal breakdown of acetylcholine. Acetylcholine is the main neurotransmitter found in the body and has functions in both the peripheral nervous system and the central nervous system.
Hence, acetylcholinesterase inhibitors, interacting with the enzyme as their primary target, are applied as relevant drugs and toxins. This review presents an overview of toxicology and pharmacology of reversible and irreversible acetylcholinesterase inactivating compounds.
- Mirjana B Colović, Danijela Z Krstić, Tamara D Lazarević-Pašti, Aleksandra M Bondžić, Vesna M Vasić
- 10.2174/1570159X11311030006
- 2013
- 2013/05
Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate ), and a terminal oxygen .
27 de ago. de 2021 · This enzyme has several important functions that are common to most of the described disorders, i.e., participation in oxidative stress and inflammatory response, role in apoptosis and role in adhesion of pathological proteins. AChE is an enzyme that degrades one of the most important neurotransmitters, ACh.
17 de jul. de 2023 · They are a group of drugs that block the normal breakdown of acetylcholine (ACh) into acetate and choline and increase both the levels and duration of actions of acetylcholine found in the central and peripheral nervous system. The acetylcholinesterase inhibitors have a variety of indications.
