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  1. Charles de Lorraine, 4th Duke of Guise and 3rd Prince of Joinville (20 August 1571 – 30 September 1640), was the son of Henry I, Duke of Guise and Catherine of Cleves, and succeeded his father as Duke of Guise in 1588.

  2. Article History. house of Guise, Noble French Roman Catholic family that played a major role in French politics during the Reformation. Claude de Lorraine (1496–1550) was created the 1st duke de Guise in 1527 for his service to Francis I in the defense of France.