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The first step of transcription for some negative, single-stranded RNA viruses is cap snatching, in which the first 10 to 20 residues of a host cell RNA are removed (snatched) and used as the 5′ cap and primer to initiate the synthesis of the nascent viral mRNA. [1]
16 de nov. de 2018 · Here, we review the current knowledge on the process of IAV cap-snatching and suggest a requirement for RNAPII promoter-proximal pausing for efficient IAV mRNA transcription.
- Corey De Vlugt, Dorota Sikora, Martin Pelchat
- 10.3390/v10110641
- 2018
- Viruses. 2018 Nov; 10(11): 641.
Cap snatching is a transcription initiation process during which a nucleotide sequence between 10 and 20 nt in size is cleaved from the 5' end of host mRNAs by an endonuclease activity encompassed within the viral RdRp .
5 de dic. de 2011 · However, they have evolved to steal caps from host mRNAs in order to prime their own viral replication, in a process known as cap snatching (Refs 105, 106, 107). Cap snatching involves three...
- Etienne Decroly, François Ferron, Julien Lescar, Julien Lescar, Bruno Canard
- 2012
7 de mar. de 2023 · To prime their own transcription, influenza A virus (IAV) and influenza B virus (IBV) use ‘cap snatching’, in which the 5′ end of fully capped host RNA is removed and attached to viral mRNAs.
- Sarah Crunkhorn
8 de may. de 2023 · The MTr1 inhibitor TFTM prevents IAV and IBV cap-snatching and thus restricts viral replication. Host 5’cap0-mRNAs are matured to cap1 mRNAs by the cellular Cap-specific mRNA (nucleoside-2’-O...
25 de jun. de 2020 · Influenza A virus (IAV), lacking its own capping machinery, produces capped mRNAs through a process known as cap-snatching. The viral polymerase associates with an actively transcribing RNA polymerase II complex and cleaves the nascent host mRNA, thereafter using the cleaved product to prime viral mRNA production.
