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29 de sept. de 2022 · David Bailey was trying to determine if the absorption of a new antihypertensive medication, felodipine, was affected by alcohol. This was a double-blind test, so Bailey needed to mask the alcohol. He tried different liquids, but ultimately found grapefruit juice was the most successful beverage.
5 de mar. de 2013 · David G Bailey 1 , George Dresser , J Malcolm O Arnold. Affiliation. 1 Lawson Health Research Institute, London, Ont. david.bailey@lhsc.on.ca. PMID: 23184849. PMCID: PMC3589309. DOI: 10.1503/cmaj.120951. No abstract available. Publication types. Review. MeSH terms. Acute Kidney Injury / chemically induced. Beverages / adverse effects*
- David G. Bailey, George Dresser, J. Malcolm O. Arnold
- 2013
23 de sept. de 2022 · Dr. David Bailey, shown holding a grapefruit in 2017, was a Canadian Olympic runner and a pharmacologist who made the game-changing discovery that consuming grapefruit juice has an effect...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989 by a group led by pharmacologist David Bailey. Their first published clinical report on grapefruit drug interactions was in 1991.
David George Bailey (March 17, 1945 – August 27, 2022) was a Canadian track and field athlete, and subsequently a recognized pharmacologist, who pioneered the research of grapefruit–drug interactions.
Felodipine has been the most extensively studied probe for grapefruit juice-drug interactions. Normally, felodipine is completely absorbed from the GI tract following oral administration ( 5 ). Thus, grapefruit juice did not act by improving drug dissolution or other pharmaceutical property of the drug formulation.
27 de nov. de 2012 · Twenty-six new drugs that can cause serious harm when mixed with grapefruit have been introduced in the past four years alone, bringing the total to 43, said Dr. David Bailey, a clinical ...
