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Steps of cap snatching. Cap-snatching occurs in three general steps: 1) The viral RdRp or N protein binds to the host mRNA 5’-methylated cap-1 or cap-2 structure. 2) Viral endonuclease cleaves mRNA several nucleotides downstream of the cap. 3) Capped RNA utilized as a primer to initiate viral mRNA synthesis carried out by the RdRp.
5 de dic. de 2011 · Key Points. mRNAs are protected at their 5′ ends by a cap structure consisting of an N7-methylated GTP molecule linked to the first transcribed nucleotide by a 5′–5′ triphosphate bond. The cap...
- Etienne Decroly, François Ferron, Julien Lescar, Julien Lescar, Bruno Canard
- 2012
16 de nov. de 2018 · During a process known as “cap-snatching”, the viral RdRp interacts with the C-terminal domain (CTD) of RNAPII and cleaves the newly synthesized transcript 10–13 nucleotides downstream of the 5′ m7G cap structure. This capped oligonucleotide primer is then used to initiate transcription from the vRNA template.
- Corey De Vlugt, Dorota Sikora, Martin Pelchat
- 10.3390/v10110641
- 2018
- Viruses. 2018 Nov; 10(11): 641.
Cap snatching is a transcription initiation process during which a nucleotide sequence between 10 and 20 nt in size is cleaved from the 5' end of host mRNAs by an endonuclease activity encompassed within the viral RdRp . For Influenza this process occurs in the nucleus whereas for most other segmented (-)RNA viruses this happens in the cytoplasm.
19 de nov. de 2014 · Influenza virus polymerase uses a capped primer, derived by ‘cap-snatching’ from host pre-messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to generate the poly...
- Stefan Reich, Delphine Guilligay, Alexander Pflug, Hélène Malet, Imre Berger, Thibaut Crépin, Darren...
- 2014
8 de may. de 2023 · Cap snatch prevention: a novel approach to tackle influenza viruses | Signal Transduction and Targeted Therapy. Research Highlight. Open access. Published: 08 May 2023. Cap snatch...
Abstract. In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs. These heterologous sequences are acquired by a so-called cap-snatching mechanism.
