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Marble burying is an animal model used in scientific research to depict anxiety or obsessive–compulsive disorder (OCD) behavior. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. [1]
24 de dic. de 2013 · The marble burying and nestlet shredding tests are good examples of behavioral methods for studying repetitive and compulsive-like behaviors in mice. Both tests show excellent face, construct and predictive validity for the human disorders they model 6-11.
- Mariana Angoa-Pérez, Michael J. Kane, Denise I. Briggs, Dina M. Francescutti, Donald M. Kuhn
- 10.3791/50978
- 2013
- J Vis Exp. 2013; (82): 50978.
We examined ten different inbred mouse strains to determine if marble-burying behavior is genetically regulated and correlated with anxiety-like traits in two other assays. We employed multiple variants of the “traditional” marble-burying assay to address how issues such as the novelty of marbles and digging behavior contribute to marble ...
- Alexia Thomas, April Burant, Nghiem Bui, Deanna Graham, Lisa A. Yuva-Paylor, Richard Paylor
- 10.1007/s00213-009-1466-y
- 2009
- 2009/06
Watch the Full Video at...
- 2 min
- 1406
- JoVE (Journal of Visualized Experiments)
25 de oct. de 2018 · Marble-burying, first described within the context of the defensive-burying test, purportedly represents a simplified application of defensive burying, and simply involves the burying of nonaversive marbles in the absence of prior conditioning or training (Poling et al., 1981).
- Geoffrey De Brouwer, Arina Fick, Brian H. Harvey, De Wet Wolmarans
- 2019
11 de abr. de 2015 · The marble burying test is used to measure repetitive and anxiety-related behaviour in rodents. The number of marbles that animals bury are count data (non-negative integers), which are bounded below by zero and above by the number of marbles present.
27 de jun. de 2006 · Digging and marble burying are species-typical behaviors that have been shown to be sensitive to animal species, strain, hippocampal lesions and other treatments 1,2,3,4,5.
