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13 de oct. de 2020 · En colaboración con Philip Siekevitz y George Palade, utilizando únicamente la técnica de fragmentación celular por centrifugación diferencial, realizó sus primeros descubrimientos; particularmente, encontró que la enzima glucosa-6-fosfatasa (G6P) es un marcador de retículo endoplásmico.
5 de abr. de 2010 · Then, in collaboration with George Palade, he demonstrated thecentral role of ribosomes in protein synthesis and, in particular, of membrane-boundribosomes in the synthesis of secretory proteins.
The hallmark of Palade’s research approach in the mid 1950s and 1960s was the integration of cell fractionation and EM data. Philip Siekevitz and Palade first demonstrated that the “microsome fraction” consisted of fragments of endoplasmic reticulum (ER) [7,8].
- Suzana M Zorca, Cornelia E Zorca
- Yale J Biol Med. 2011 Jun; 84(2): 113-116.
- 2011
- 2011/06
Keith Porter and George Palade, who at the Rockefeller Institute were making trailblazing discoveries with the electron microscope on the identification and structure of subcellular organelles, were among the many who appreciated Siekevitz’s development of an in vitro protein-synthesizing system.
- David D. Sabatini
- 2010
Hace 2 días · In 1955, Palade recruited Phil Siekevitz to the Rockefeller Institute, with whom he undertook the task of characterizing the microsomal fraction, which they showed consisted of closed...
- David D Sabatini
- 2008
Nobel Lecture, December 12, 1974. by. GEORGE E. PALADE. Yale University Medical School, New Haven, Connecticut, U.S.A. A SHORT HISTORY OF THE WO R K. In the early 1950’s, during the near avalanche of discoveries, rediscoveries, and redefinitions of subcellular components made possible by electrons micros-copy, those prospecting in this newly ...
Philip Siekevitz was integral to many aspects of the cell biology laboratory at Rockefeller University,guiding many students and postdoctoral fellows and collaborating with George Palade...
