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18 de oct. de 2021 · Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic changes. Among these changes is the release of numerous biologically active molecules collectively ...
11 de ago. de 2022 · Cellular senescence was first reported in 1961 by Hayflick and Moorhead after serially subculturing human fibroblasts 37.Senescent cells, which are in a state of essentially irreversible cell ...
细胞衰老是指稳定细胞周期停滞的状态，在这种状态下增殖细胞会对促生长刺激产生耐受，通常由 DNA 损伤所引起。. Leonard Hayflick 首先描述了细胞衰老，他观察到人类胎儿成纤维细胞最终会停止分裂，但在长时间培养后仍然具有活力和代谢活性。. 现在普遍认为 ...
1 de mar. de 2023 · How cellular senescence impacts our physiology and pathology over the lifespan has been a focal point of research in the past decade. This is partly due to the apparent paradox of senescent cells being critical for maintaining good health by suppressing tumourigenesis, but also being associated with driving disease and poor health during ageing.
2 de abr. de 2018 · Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different stresses. By imposing a growth arrest, senescence limits the replication of old or damaged cells. Besides exiting the cell cycle, senescent cells undergo many other phenotypic alterations such as metabolic reprogramming, chromatin rearrangement ...
Hace 4 días · Cellular senescence and the process of transcription are intimately linked, yet the mechanisms involved remain unclear. Here the authors show that a defect in TFIIS leads to telomere dysfunction ...
Cellular senescence can be induced by DNA damage, telomere shortening, oxidative stress, and oncogenes. Interestingly, all of these senescence-inducing conditions impinge on DNA directly or indirectly. Here we showed that the DNA sensor cGAS is essential for cellular senescence during spontaneous immortalization or in response to DNA damaging ...
