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Steps of cap snatching. Cap-snatching occurs in three general steps: 1) The viral RdRp or N protein binds to the host mRNA 5’-methylated cap-1 or cap-2 structure. 2) Viral endonuclease cleaves mRNA several nucleotides downstream of the cap. 3) Capped RNA utilized as a primer to initiate viral mRNA synthesis carried out by the RdRp.
16 de nov. de 2018 · During a process known as “cap-snatching”, the viral RdRp interacts with the C-terminal domain (CTD) of RNAPII and cleaves the newly synthesized transcript 10–13 nucleotides downstream of the 5′ m7G cap structure. This capped oligonucleotide primer is then used to initiate transcription from the vRNA template.
19 de nov. de 2014 · Influenza virus polymerase uses a capped primer, derived by ‘cap-snatching’ from host pre-messenger RNA, to transcribe its RNA genome into mRNA and a stuttering mechanism to generate the poly...
5 de dic. de 2011 · Key Points. mRNAs are protected at their 5′ ends by a cap structure consisting of an N7-methylated GTP molecule linked to the first transcribed nucleotide by a 5′–5′ triphosphate bond. The cap...
Abstract. In common with all segmented negative-sense RNA viruses, bunyavirus transcripts contain heterologous sequences at their 5' termini originating from capped host cell RNAs. These heterologous sequences are acquired by a so-called cap-snatching mechanism.
7 de mar. de 2023 · Inhibiting cap snatching. RESEARCH HIGHLIGHT. 07 March 2023. Inhibiting cap snatching. By. Sarah Crunkhorn. To prime their own transcription, influenza A virus (IAV) and influenza B virus...
25 de jun. de 2020 · Influenza A virus (IAV), lacking its own capping machinery, produces capped mRNAs through a process known as cap-snatching. The viral polymerase associates with an actively transcribing RNA polymerase II complex and cleaves the nascent host mRNA, thereafter using the cleaved product to prime viral mRNA production.
