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La coenzima A ( CoA, CoASH o HSCoA) es una coenzima, notable por su papel en la biosíntesis y la oxidación de ácidos grasos, así como en la descarboxilación oxidativa del ácido pirúvico, paso previo al ciclo de Krebs. Su molécula consta de ácido pantoténico (vitamina B 5 ), adenosín difosfato y cisteamina. 2 .
- C₂₁H₃₆N₇O₁₆P₃S
- CoA, CoASH, HSCoA
- 85-61-0[1]
Coenzyme A is one of five crucial coenzymes that are necessary in the reaction mechanism of the citric acid cycle. Its acetyl-coenzyme A form is the primary input in the citric acid cycle and is obtained from glycolysis, amino acid metabolism, and fatty acid beta oxidation.
- C₂₁H₃₆N₇O₁₆P₃S
- 259.5 nm
- 767.535
- ε₂₅₉ = 16.8 mM−1 cm−1
Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. Its main function is to deliver the acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production.
- C₂₃H₃₈N₇O₁₇P₃S
- 260 nm; 232 nm
- 809.57 g·mol−1
- .mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}72-89-9 (free acid)
Coenzyme A ( CoA, CoASH, or HSCoA) is a coenzyme, well known for it's role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it, or a thioester form of it, as a substrate.
2 de ago. de 2021 · Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties.
- Luca Mignani, Barbara Gnutti, Daniela Zizioli, Dario Finazzi
- 10.3390/brainsci11081031
- 2021
- Brain Sci. 2021 Aug; 11(8): 1031.
Coenzima. Las coenzimas son cofactores orgánicos no proteicos, termoestables, que unidos a una apoenzima constituyen la holoenzima o forma catalíticamente activa de la enzima. Tienen en general baja masa molecular (al menos comparada con la apoenzima) y son claves en el mecanismo de catálisis, por ejemplo, aceptando o donando electrones o ...
9 de jul. de 2020 · Definition. Acetyl-CoA or acetyl coenzyme A is a component of cellular respiration (energy conversion) that adds acetyl groups to biochemical reactions. These reactions are used in the metabolizing of proteins, carbohydrates, and lipids that will provide energy sources in the forms of adenosine triphosphate (ATP), lactic acid, and ketone bodies.
