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Carboxylesterase 1 is a serine esterase and member of a large multigene carboxylesterase family. It is also part of the alpha/beta fold hydrolase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing xenobiotics and drugs such as cocaine and heroin.
- Carboxylesterase
The enzyme carboxylesterase (or carboxylic-ester hydrolase,...
- Carboxylesterase
25 de jun. de 2018 · Abstract. Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester ...
- Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang
- 10.1016/j.apsb.2018.05.005
- 2018
- Acta Pharm Sin B. 2018 Sep; 8(5): 699-712.
1 de sept. de 2018 · Under a Creative Commons license. open access. Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade.
- Dandan Wang, Liwei Zou, Qiang Jin, Jie Hou, Guangbo Ge, Ling Yang
- 2018
17 de oct. de 2019 · Carboxylesterase (CES) 1 is a phase I drug-metabolizing enzyme (DME) responsible for 80%–95% of total hydrolytic activity in the liver ( Imai et al., 2006 ); it metabolizes a wide range of drugs, pesticides, environmental pollutants, and endogenous compounds, including lipid esters ( Table 1 ).
- Lucy Her, Hao-Jie Zhu
- 10.1124/dmd.119.089680
- 2020
- Drug Metab Dispos. 2020 Mar; 48(3): 230-244.
Carboxylesterases are a multi-gene family of enzymes widely distributed throughout the body of mammals that catalyze the hydrolysis of esters, amides, thioesters, and carbamates. In humans, two carboxylesterases, hCE1 and hCE2, are important pathways of drug metabolism.
Carboxylesterase 1. Human carboxylesterase 1 (hCE1 or CES1) is a serine esterase that hydrolyzes a variety of endogenous and exogenous substrates [38]. From: Critical Issues in Alcohol and Drugs of Abuse Testing (Second Edition), 2019. Related terms: Hydrolase; Sulfotransferase; Carboxylesterase; Enzymatic Hydrolysis; Lipid Droplet ...
