Yahoo Search Búsqueda en la Web

Entrar

Resultado de búsqueda

  1. en.wikipedia.org › wiki › Flavin-containingFlavin-containing monooxygenase 3 - Wikipedia

    Flavin-containing monooxygenase 3 (FMO3), also known as dimethylaniline monooxygenase [N-oxide-forming] 3 and trimethylamine monooxygenase, is a flavoprotein enzyme (EC 1.14.13.148) that in humans is encoded by the FMO3 gene. This enzyme catalyzes the following chemical reaction, among others:

  2. en.wikipedia.org › Flavin-containing_monooxygenaseFlavin-containing monooxygenase - Wikipedia

    The flavin-containing monooxygenase ( FMO) protein family specializes in the oxidation of xeno-substrates in order to facilitate the excretion of these compounds from living organisms. [1] . These enzymes can oxidize a wide array of heteroatoms, particularly soft nucleophiles, such as amines, sulfides, and phosphites.

  3. www.ncbi.nlm.nih.gov › pmc › articlesFlavin-Containing Monooxygenase 3 (FMO3) Is Critical for ...

    18 de abr. de 2022 · Here, we show that TCDD exposure in mice profoundly stimulates the hepatic expression of flavin-containing monooxygenase 3 (Fmo3), which is a hepatic xenobiotic metabolizing enzyme that is also responsible for the production of the gut microbiome-associated metabolite trimethylamine N-oxide (TMAO).

    • 10.3390/metabo12040364
    • 2022/04
    • Metabolites. 2022 Apr; 12(4): 364.

  4. www.nature.com › articles › s41594/019/0356-1Flavin-containing monooxygenases: new structures from old ...

    23 de dic. de 2019 · Nature Structural & Molecular Biology - A study reports the structures of membrane-bound flavin-containing monooxygenases (FMOs), solved using reconstructed ancestral mammalian FMOs. The...

    • Ian R Phillips, Ian R Phillips, Elizabeth A Shephard
    • 2020

  5. www.ncbi.nlm.nih.gov › pmc › articlesMammalian flavin-containing monooxygenases: structure ...

    Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a “soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P 450 (CYP), is a monooxygenase, utilizing the reducing equivalents of NADPH to reduce 1 atom of molecular oxygen to water, while the other atom is used to oxidize the substrate.

  6. www.nature.com › articles › s41467/023/36756-xEvolution of enzyme functionality in the flavin-containing ...

    24 de feb. de 2023 · The flavin-containing monooxygenases (FMOs) are enzymes and key assets in vertebrates detoxification arsenal 1, 2. FMOs are generally known for their ability to convert heteroatom-containing...

  7. pubmed.ncbi.nlm.nih.gov › 31317802Flavin-containing monooxygenase 3 (FMO3): genetic variants ...

    The review focuses on genetic variants of human flavin-containing monooxygenase 3 (FMO3) and their impact on enzyme activity, drug metabolism and disease.The majority of FMO-mediated metabolism in adult human liver is catalyzed by FMO3. Some drugs are metabolized in human liver predominantly by FMO3 …