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William Frank Rose was born on September 16, 1909, in Pittsburgh, Pennsylvania. He studied at the University of Pittsburgh and the College of Fine Arts at the Carnegie Institute. At Carnegie, he was an editor of student publications and a member of the Jewish fraternity Beta Sigma Rho; he graduated in 1930 with a B.A. in painting and decorating.

Rose lived and worked in the New York metropolitan area, residing in the suburban hamlet of Oceanside on Long Island. He was a member of the New York-based professional Society of Illustrators, which featured his artwork in its 1945 and 1946 annual exhibitions. His artwork was also displayed at the 1966 Pennsylvania Academy of the Fine Arts annual ...

Rose was married to Miriam Roberts Rose, a concert pianist from New York. Their wedding took place on October 9, 1935, in Pittsburgh. She gave recitals in both Pennsylvania and New York and worked for many years as a private piano teacher. They had two daughters, Penny and Tina. Miriam Rose died at age 51 at Manhattan's Lenox Hill Hospital on March...