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Mechanism. Glucuronidation consists of transfer of the glucuronic acid component of uridine diphosphate glucuronic acid to a substrate by any of several types of UDP-glucuronosyltransferase . UDP-glucuronic acid (glucuronic acid linked via a glycosidic bond to uridine diphosphate) is an intermediate in the process and is formed in ...
- Glucuronide
Glucuronidation, the conversion of chemical compounds to...
- UGT1A9
Function [ edit] This gene encodes a...
- Glucuronide
Glucuronidation, the conversion of chemical compounds to glucuronides, is a method that animals use to assist in the excretion of toxic substances, drugs or other substances that cannot be used as an energy source.
Un glucurónido, también conocido como glucuronósido, es cualquier sustancia producida por la unión del ácido glucurónico a otra sustancia a través de un enlace glucosídico. 1 Los glucurónidos pertenecen a los glucósidos . La glucuronidación, es la conversión de compuestos químicos en glucurónidos, es un método que los animales ...
Function [ edit] This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
- UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT 1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I, UGT1A9S, UDP glucuronosyltransferase family 1 member A9
Properties. Functions. Proteoglycans. Glucuronidation. Role in disease. Use. See also. References. Glucuronic acid (from Greek γλεῦκος " sweet wine, must " and οὖρον " urine ") is a uronic acid that was first isolated from urine (hence the name "uronic acid").
- C₆H₁₀O₇
- 194.139 g·mol−1
- 159 to 161 °C (318 to 322 °F; 432 to 434 K)
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Glucuronosyltransferases are responsible for the process of glucuronidation, a major part of phase II metabolism. Arguably the most important of the Phase II (conjugative) enzymes, UGTs have been the subject of increasing scientific inquiry since the mid-to-late 1990s.
El ácido glucurónico (del griego: γλυκερός, dulce) es un ácido carboxílico similar a la glucosa que presenta un grupo carboxilo en el carbono 6. Su fórmula química es C 6 H 10 O 7. Las sales de este ácido se denominan glucuronatos; el anión, C 6 H 9 O 7−, es el ion glucuronato .
