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  1. Sir Augustus Frederick d'Este, KCH (13 January 1794 – 28 December 1848) was a relative of the British royal family and the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made.

    • Augustus Frederick Hanover, 13 January 1794, London, Great Britain
    • 28 December 1848 (aged 54), Ramsgate, Kent
  2. Sir Augustus Frederick D’Esté (1794–1848) was an illegitimate royal child, a bachelor, an active member of the Aborigines Protection Society, and the earliest known person diagnosed with multiple sclerosis. For 24 years D’Esté kept a diary, currently held in the Royal College of Physicians’ archives, which documents what he called ‘my case’.

  3. La esclerosis múltiple (EM) fue descrita inicialmente en un documento escandinavo y dos siglos más tarde en el diario de una santa holandesa. Mucho después, comenzando el siglo XVIII, se reportó un caso aislado y no es sino hasta el siglo XIX cuando la enfermedad se presenta con mayor frecuencia.

  4. 17 de oct. de 2009 · The personal diary of Sir Augustus d’Esté, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease.

    • Anne Marie Landtblom, Patrik Fazio, Sten Fredrikson, Enrico Granieri
    • 2010
  5. Sir Augustus Frederick d'Este (1794–1848) escribió su diario desde 1822 a 1846 relatando sus síntomas neurológicos recurrentes y discapacitantes asociados a una enfermedad que aún no sabía que se llamaría Esclerosis Múltiple.

  6. The personal diary of Sir Augustus d'Esté, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS)....

  7. The illness of Augustus d'Este. Written by Enrico Granieri. TWe owe our first record of multiple sclerosis to a descendent of the Este. ''An 'Estense' neurologist is not complete without this book especially when his main love is multiple sclerosis''.