Giovanni di Lorenzo de' Medici was born on 11 December 1475 in the Republic of Florence, the second son of Lorenzo the Magnificent, head of the Florentine Republic, and Clarice Orsini. From an early age Giovanni was destined for an ecclesiastical career. He received the tonsure at the age of seven and was soon granted rich benefices and preferments
León X, de nombre secular Giovanni di Lorenzo de' Medici (Florencia, 11 de diciembre de 1475-Roma, 1 de diciembre de 1521) fue el papa 217.º de la Iglesia católica de 1513 a 1521
Clarice Orsini (1453 - 1488), spouse of Lorenzo il Magnifico; Fabio Orsini (1476-1504) Gerolama Orsini, (1503 - 1570), noble; Giovanni II Orsini, Count of Cefalonia and Zante, despota dell'Epiro 1323 – 1335; Giovanni Antonio del Balzo Orsini, (1386 or 1393 - 1463), noble of the Kingdom of Naples, prince of Taranto, count of Lecce and duke Bari.
Lara Pulver, Actress: Sherlock. Lara was born and raised in Essex, UK. She studied drama with the NYMT and went on to gain a BA Honours degree in Theatre. Lara's extensive theatre career led her to gain a Laurence Olivier Award nomination for her portrayal of "Lucille Frank" in Rob Ashford's production of "Parade" at The Donmar Warehouse.
Lorenzo heiratete 1468/69 die Adlige Clarice Orsini (1453–1488), Tochter von Jacopo Orsini von Monterotondo. Von ihren 10 Kindern verstarben 3 früh. Lucrezia (1470–1553) heiratete 1486 Jacopo Salviati (1461–1533)
Piero di Lorenzo de' Medici was the eldest son of Lorenzo de' Medici (Lorenzo the Magnificent) and Clarice Orsini. He was raised alongside his younger brother Giovanni, who would go on to become Pope Leo X , and his cousin Giulio, who would later become Pope Clement VII .
Lorenzo di Piero de' Medici (Firenze, 12 settembre 1492 – Firenze, 4 maggio 1519), unico figlio maschio non morto infante di Piero "il Fatuo" de' Medici e di Alfonsina Orsini, fu signore di Firenze e il primo ed unico duca di Urbino della dinastia Medici.