In Weimar on 26 May 1555 John Frederick II married his first wife, Agnes of Hesse, Dowager Electress of Saxony. Six months later she suffered a miscarriage and died, on 4 November 1555. In Weimar on 12 June 1558 John Frederick II married his second wife, Countess Palatine Elisabeth of Simmern-Sponheim , daughter of the later (1559) Frederick III, Elector Palatine .
Frederick ensured that Martin Luther would be heard before the Diet of Worms in 1521 and secured an exemption from the Edict of Worms for Saxony. Frederick collected many relics in his castle church; his inventory of 1518 listed 17,443 items, including a thumb from St. Anne, a twig from Moses' burning bush, hay of the holy manger, and milk from the Virgin Mary.
Hedwige of Saxony (also Hedwig, German: Hadwig von Sachsen; c. 910 – after 958), a member of the Ottonian dynasty, was Duchess consort of the Franks by her marriage to the Robertian duke Hugh the Great. Upon her husband's death in 956, she acted as a regent during the minority of their son Hugh Capet, the founder of the Elder House of Capet