In Weimar on 26 May 1555 John Frederick II married his first wife, Agnes of Hesse, Dowager Electress of Saxony. Six months later she suffered a miscarriage and died, on 4 November 1555. In Weimar on 12 June 1558 John Frederick II married his second wife, Countess Palatine Elisabeth of Simmern-Sponheim , daughter of the later (1559) Frederick III, Elector Palatine .
John of Saxony: 4. George of Saxony: 9. Princess Amalie Auguste of Bavaria: 2. Frederick Augustus III of Saxony: 10. Ferdinand II of Portugal: 5. Infanta Maria Anna of Portugal: 11. Maria II of Portugal: 1. Georg, Crown Prince of Saxony: 12. Leopold II, Grand Duke of Tuscany: 6. Ferdinand IV, Grand Duke of Tuscany: 13. Princess Maria Antonia of ...