Lucrezia, Cesare and Alexander play key roles in Cecelia Holland's 1979 historical novel City of God: A Novel of the Borgias. In Roberta Gellis's 2003 novel Lucrezia Borgia and the Mother of Poisons (ISBN 9780765306616), Alfonso d'Este of Ferrara accuses Lucrezia of murder, and she must solve the crime and expose the true murderer.
Eleanor of Toledo, Duchess of Florence, who purchased the Palazzo Pitti in 1549 for the Medici family. In 1539, Cosimo married the Spanish noblewoman Eleanor of Toledo (1522 – 1562), the daughter of Don Pedro Álvarez de Toledo , the Spanish viceroy of Naples and third cousin to Emperor Charles V himself.
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