On 15 February 1877 at Arolsen, Marie married, Prince William of Württemberg (later King William II of Württemberg). They had three children: Princess Pauline (19 December 1877 - 7 May 1965), married William Frederick, Prince of Wied (1872–1945) Prince Ulrich (28 July 1880 - 28 December 1880) stillborn daughter (24 April 1882) Death
In the spring of 1918, newspapers announced the prince's engagement to Duchess Marie Amelia, daughter of Albrecht, Duke of Württemberg, the heir to the throne of the Kingdom of Württemberg. The end of the Saxon monarchy and the prince's desire to become a priest apparently led to the end of the engagement. The duchess died unmarried in 1923.