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3 de ago. de 2022 · Cellular senescence is a ubiquitous process with roles in tissue remodelling, including wound repair and embryogenesis. However, prolonged senescence can be maladaptive, leading to cancer...
16 de dic. de 2020 · Cellular senescence occurs in response to many different triggers, including DNA damage, telomere dysfunction, oncogene activation and organelle stress, and has been linked to processes such as...
- Raffaella Di Micco, Valery Krizhanovsky, Darren Baker, Fabrizio d’Adda di Fagagna
- 2021
25 de nov. de 2021 · In simple terms, cellular senescence refers to a highly stable cell cycle arrest that acts as a defence mechanism in response to different stresses—these include oncogenic activation, tumour suppressor gene inactivation, oxidative stress, telomere attrition, mitochondrial dysfunction, as well as DNA-damage causing agents, such as ...
- 10.3390/biomedicines9121769
- 2021/12
- Biomedicines. 2021 Dec; 9(12): 1769.
10 de abr. de 2022 · Senescence is the process of the stable and irreversible growth arrest of cells. This process contributes to aging and age-related diseases, but also physiologically protects multicellular organisms from neoplasia [ 1 ].
- 10.3390/ijms23084168
- 2022/04
- Int J Mol Sci. 2022 Apr; 23(8): 4168.
29 de mar. de 2021 · The figure shows the different intrinsic and extrinsic stimuli capable of inducing cellular senescence. Key pathways involved in manifesting cell cycle arrest in senescence such as p53/p21 WAF1/CIP1 and p16 INK4A /RB tumor suppressor pathways, DDR, AMPK, p38/MAPK, PI3K/AKT/mTOR are illustrated.
- Ruchi Kumari, Parmjit Jat
- 10.3389/fcell.2021.645593
- 2021
- Front Cell Dev Biol. 2021; 9: 645593.
Cellular senescence is a cell state triggered by stressful insults and certain physiological processes, characterized by a prolonged and generally irreversible cell-cycle arrest with secretory features, macromolecular damage, and altered metabolism ( Figure 1 ).
23 de may. de 2022 · Cell senescence acts as a potent tumour-suppressive mechanism limiting the proliferation of cells at risk of malignant transformation and supports the repair of acute tissue damage, but also represents a key driver of ageing and age-related diseases. Main text.
