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  1. 12 de abr. de 2007 · Our study, the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial, was designed to determine whether PCI coupled with optimal medical therapy...

  2. 13 de sept. de 2012 · The aim of this trial was to determine whether FFR-guided PCI with drug-eluting stents plus the best available medical therapy is superior to the best available medical therapy alone in reducing...

    • Bernard De Bruyne, Bindu Kalesan, Emanuele Barbato, Zsolt Piroth, Nikola Jagic, Sven Mobius-Winckler...
    • 2012
  3. The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial was designed to determine whether percutaneous coronary intervention (PCI) coupled with optimal medical therapy (OMT) reduced the risk of death or nonfatal myocardial infarction in patients with stable c ….

    • William E Boden
    • 2009
  4. The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) trial was a strategy-driven trial randomizing 2287 patients to optimal medical therapy (OMT) with or without percutaneous coro- nary intervention (PCI).6The main trial results revealed no difference by treatment in the primary end point of death or acute m...

  5. 11 de mar. de 2015 · This study reports the largest series to date on ischemia reduction with medical therapy in a clinical trial. The COURAGE trial, utilizing meticulous risk factor control and lifestyle management strategies as well as targeted anti-ischemic therapies, was able to reduce ischemia in nearly 1 in 5 OMT patients.

  6. The COURAGE trial was designed to lessen or eliminate the impact of several of these factors. Case management or chronic care supervision coordinated by nurses, 1 of several mechanisms to reduce fragmentation and identify modifiable patient-specific conditions, has had a salutary effect on both adherence and outcomes in patients with heart ...