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2 de may. de 2024 · Bert Vogelstein (born June 2, 1949, Baltimore, Md., U.S.) is an American oncologist known for his groundbreaking work on the genetics of cancer. Vogelstein was raised in Baltimore and attended a private middle school from which he was often truant, preferring to teach himself by reading at the public library.
- The Editors of Encyclopaedia Britannica
Hace 3 días · There are series from Washington University in Saint Louis, Dana-Farber Cancer Center and the Broad Institute in Boston, and studies from Bert Vogelstein's lab at Johns Hopkins that have done whole genome sequencing on colon cancer. We are beginning to see that fewer than 200 genes are the major culprits in colon cancer.
9 de may. de 2024 · El trabajo de Zaidi surge de importantes descubrimientos realizados por investigadores de Johns Hopkins como Bert Vogelstein y Elizabeth Jaffee. Vogelstein, por ejemplo, descubrió que las...
7 de may. de 2024 · As an intrinsic cellular pathway, nonsense- mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted a high throughput screen, based on the ratiometric analysis of transcripts, to identify critical mediators of NMD.
14 de may. de 2024 · 伯特·沃格尔斯坦 （英語： Bert Vogelstein ；1949年6月2日 — ），美国癌症研究者、 霍华德·休斯医学研究所 研究员。 生平. 他是 癌症基因组学 领域的先驱，基于对 大肠癌 的研究，他于1988年提出一个人类癌症模型，假设连续积累的癌基因和抑癌基因的突变可以导致癌症。 p53 是首个印证这一假说的基因。 1991年他与人合作发现了另一抑癌基因 APC 。 这些研究为现在许多现代癌症研究扫除了道路。 奖项和荣誉. 沃格尔斯坦于1992年获 盖尔德纳国际奖 ，1998年获 霍维茨奖 ，2004年获 阿斯图里亚斯亲王奖 科学技术奖 [2] ，2013年获 生命科学突破奖 ，2018年获 丹·大卫奖 [3] 。
15 de may. de 2024 · The authors thank Kathrin Jäger at the core unit for performing flow cytometry, Bert Vogelstein for the kind gift of HCT116 cells, Roger Watson for generously providing the anti-B-MYB monoclonal antibody, and Christine Engeland for critically reading the manuscript. Author contributions: R.K. and K.E. developed the study.
8 de may. de 2024 · HHMI investigator Bert Vogelstein and colleagues at the Johns Hopkins Kimmel Cancer Center, in collaboration with investigators at Duke University and elsewhere, sequenced 20,661 genes in cells...
