Sofosbuvir is activated in the liver to the triphosphate GS-461203 by hydrolysis of the carboxylate ester by either of the enzymes cathepsin A or carboxylesterase 1, followed by cleaving of the phosphoramidate by the enzyme histidine triad nucleotide-binding protein 1 (HINT1), and subsequent repeated phosphorylation.
Die Pseudocholinesterase (auch Butyrylcholinesterase, BuChE) ist ein Enzym, das die hydrolytische Spaltung der Esterbindung in Cholinestern katalysiert. Sie ist damit im Stoffwechsel von Chordatieren neben der Acetylcholinesterase unverzichtbar zum Abbau dieser Stoffe.
Rotor syndrome (also known as Rotor type hyperbilirubinemia) is a rare cause of mixed direct (conjugated) and indirect (unconjugated) hyperbilirubinemia, relatively benign, autosomal recessive bilirubin disorder characterized by non-hemolytic jaundice due to the chronic elevation of predominantly conjugated bilirubin.
Nature Chemistry 的ISO4标准期刊缩写为 Nat. Chem.。简单的说，当您需要引用期刊Nature Chemistry时，符合ISO4 ...
two nitrogen-containing bases pair together between double-stranded dna; only specific combinations of these bases (e.g., adenine with thymine; guanine with cytosine) are possible, a fact which facilitates accurate dna replication; when quantified (e.g., 8 base pairs, or bp), this term refers to the actual number of base pairs in a sequence of nucleotides.
There is minimal metabolism via hydrolysis (mediated by carboxylesterase 1), conjugation, and oxidation by CYP3A4. The predominant metabolite M-4, formed by hydrolysis, is human-specific and active and reaches less than 10% of the exposure of the parent compound in healthy subjects.
· The Biochemical and Biophysical Research Communications has published 0 reports and received 1 citations in 1958. Biochemical and Biophysical Research Communications Key Factor Analysis · Biochemical and Biophysical Research Communicationsは、1958年に0件のレポートを公開し、1件の引用を受けました。