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Function. Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters.
11 de nov. de 2016 · Carboxylesterase are general detoxifying enzymes that hydrolyze esterified molecules. They are expressed in tissues likely to be exposed to such agents. Humans and small mammals demonstrate different levels of carboxylesterase expression. Organophosphorus compounds are irreversibly inhibitors of these enzymes. Go to:
31 de ene. de 2012 · Abstract. Carboxylesterases (CESs, E.C.3.1.1.1) constitute a large class of enzymes that hydrolyze chemicals containing such a functional group as a carboxylic acid ester, amide, and thioester. These enzymes are major pharmacokinetic determinants of ester/amide drugs and detoxify against organophosphorus and pyrethroid insecticides.
4.14.5.3 CES. The carboxylesterase genes (CES1, CES2, and CES3) map to human chromosome 16, location 16q13–q22.1. The CES1 gene contains 14 exons and spans approximately 30 kb on the minus strand. The closest neighboring genes are CES7 and the pseudo-gene CES4.
14 de abr. de 2016 · Xu, J. et al. Hepatic carboxylesterase 1 is essential for both normal and farnesoid X-receptor-controlled lipid homeostasis. Hepatology 59, 1761–1771, 10.1002/hep.26714 (2014).
25 de sept. de 2006 · Introduction. The present review highlights the importance of structure in delineating overall function, substrate specificity, regulation and localization of mammalian carboxylesterases (CarbEs). They are α,β-hydrolase-fold protein and comprise a multigene superfamily [1]. Structural considerations emerge from the genes encoding the family.
Carboxylesterase or esterase is a common term for enzymes that hydrolyze endogenous and exogenous esters. A systematic nomenclature for the classification of these enzymes remains to be established and multiple systems are currently used. According to the International Union for. Fig. 1. Esterase hydrolysis mechanism.
