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Human carboxylesterase 1 (hCE1) is a serine esterase involved in both drug metabolism and activation, as well as other biological processes. hCE1 catalyses the hydrolysis of heroin and cocaine, and the transesterification of cocaine in the presence of ethanol to the toxic metabolite cocaethylene. We have determined the crystal structures of ...
Trong enzymology, một carboxylesterase hoặc hydrolase carboxylic-ester (EC 3.1.1.1) là một enzyme xúc tác cho một phản ứng hóa học có dạng: một carboxylic ester + H 2 O Một alcohol + một carboxylate. Vì vậy, hai chất nền của enzym này là carboxylic ester và H2O, trong khi hai sản phẩm của nó là ...
Introduction. Mammalian carboxylesterases (CES, EC 3.1.1.1) are a well conserved multi-gene family of α,β-hydrolase-fold proteins that catalyze the hydrolysis of a vast array of endogenous and exogenous substrates including environmental toxins and drugs. 1-3 Though generally ignored at the clinical level, carboxylesterase-mediated hydrolysis plays an important role in the disposition of a ...
Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers, comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80%-95% of total hydrolytic activity in the liver and plays a crucial role in the metabolism of a wide range of drugs (especially ester-prodrugs), pesticides, environmental ...
5 de feb. de 2013 · Mammalian carboxylesterases (EC 3.1.1.1) are a well conserved multigene family of α,β-hydrolase fold proteins that catalyze the hydrolysis of a vast array of endogenous and exogenous substrates including many environmental toxins and drugs. 1-3 Though generally ignored at the clinical level, carboxylesterase-mediated hydrolysis plays an important role in the disposition of a number of widely ...
Function. Carboxylesterase 3 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters.
25 de jun. de 2018 · Mammalian carboxylesterases (CES, E.C. 3.1.1.1) are essential members of the serine hydrolase superfamily, which are localized within the lumen of the endoplasmic reticulum in many tissues1, 2, 3. As their name implies, CES catalyze the ester cleavage of a large number of structurally diverse ester- or amide-containing substrates into the corresponding alcohol and carboxylic acid 1 , 2 , 3 .
