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Hace 5 días · The spike protein is very large, often 1200 to 1400 amino acid residues long; it is 1273 residues in SARS-CoV-2. It is a single-pass transmembrane protein with a short C-terminal tail on the interior of the virus, a transmembrane helix, and a large N-terminal ectodomain exposed on the virus exterior.
7 de may. de 2024 · Protein Function; ORF1ab: Replicase/transcriptase polyprotein (pp1ab) (nonstructural proteins) ORF2: Spike (S) protein, virus binding and entry (structural protein) ORF3a: Interacts with S, E, M structural proteins; Ion channel activity; Upregulates cytokines and chemokines such as IL-8 and RANTES; Upregulates NF-κB and JNK;
14 de may. de 2024 · Due to the importance of COVID-19 vaccine development, spike (S) is the most studied SARS-CoV-2 protein. S facilitates virus entry by binding to the host receptor angiotensin-converting...
Hace 3 días · The protein of interest is the spike protein, a protein on the exterior of the virus that enables SARS-type coronaviruses to enter cells through the ACE2 receptor. Following vaccination, the production of coronavirus spike protein within the body will cause the immune system to attack the spike protein with antibodies and T-cells if ...
- AU: B1
- SARS-CoV-2
- Vaxzevria, Covishield
- Viral vector
26 de abr. de 2024 · Key points. SARS-CoV-2 continues to circulate and evolve with important genetic and antigenic evolution of the spike protein. The objective of an update to COVID-19 vaccine antigen composition is to enhance vaccine-induced immune responses to circulating SARS-CoV-2 variants.
Hace 6 días · Several lines of evidence suggest that the spike protein from SARS-CoV-2 can induce cytokine expression 2, 11, 12, 13, 14, 15, 16. In addition to the spike protein (S), which has two...
4 de may. de 2024 · Published: 04 May 2024. Immunoinformatics design of a structural proteins driven multi-epitope candidate vaccine against different SARS-CoV-2 variants based on fynomer. Javad Sarvmeili,...
